Hydroxypropyl Betadex (HPBCD) CAS 128446-35-5 | Pharmaceutical Cyclodextrin Excipient
Chemical Name: Hydroxypropyl Beta Cyclodextrin
CAS Number: 128446-35-5
Product Category: Pharmaceutical Excipient
Main Function: Drug solubility enhancement and inclusion complex formation
Appearance: White or almost white amorphous powder
Water Solubility: Highly soluble in water
Applications: Drug formulation, injectable preparations, oral formulations, and topical drugs
Quality Standard: USP / EP / ChP Pharmaceutical Grade
Hydroxypropyl Betadex (HPBCD) is a modified β-cyclodextrin widely used as a pharmaceutical excipient to improve the solubility, stability, and bioavailability of poorly soluble drugs. It forms inclusion complexes with active pharmaceutical ingredients, enhancing drug delivery performance in oral and parenteral formulations.
| Item | Specification |
|---|---|
| Appearance | White or almost white amorphous powder |
| Identification | Conforms |
| Average Degree of Substitution | 0.4 – 1.5 |
| Water Content | ≤ 10.0% |
| pH (1% Solution) | 5.0 – 7.5 |
| Residue on Ignition | ≤ 0.2% |
| Heavy Metals | ≤ 10 ppm |
| Propylene Glycol | ≤ 0.5% |
| Microbial Limit | Complies with USP requirements |
| Assay | Conforms to USP |
Standard: USP / EP / ChP (Pharmaceutical Grade Available)
The above specifications comply with pharmaceutical standards such as USP, EP, and ChP. Detailed Certificate of Analysis (COA) is available upon request.
Hydroxypropyl Betadex is widely used in pharmaceutical formulations including:
Hydroxypropyl Betadex is used as a pharmaceutical excipient to enhance the solubility, stability, and bioavailability of poorly soluble drugs.
Yes. Pharmaceutical-grade HPBCD is widely used in injectable drug formulations and is included in several approved pharmaceutical products.
HPBCD forms inclusion complexes with hydrophobic drug molecules, allowing them to dissolve more easily in aqueous environments.
HPBCD is a modified form of β-cyclodextrin with hydroxypropyl groups that significantly improve water solubility and reduce toxicity.
It is mainly used in pharmaceutical formulations, veterinary drugs, and advanced drug delivery systems.
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Product: Hydroxypropyl Betadex (HPBCD)
CAS: 128446-35-5
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