Betadex Sulfobutyl Ether Sodium CAS NO 182410-00-0 is a cyclodextrin derivativea and a China DELI's new kind of pharmaceutical excipients.
Betadex Sulfobutyl Ether Sodium CAS NO 182410-00-0 is a China DELI's new type of anionic high soluble cyclodextrin derivatives. Betadex Sulfobutyl Ether Sodium CAS NO 182410-00-0 is a sodium salt produced when Betadex is alkylated by 1,4-butanesulfonic acid lactone under alkaline conditions. It is an anion, highly water-soluble Betadex derivative. It can be used as a solubilizer, wetting agent, chelating agent (complexing agent) and polyvatent masking agent.
[Period of validity]: 36 months
1. Application in injection
Role: Solubilizer, stabilizer, improve the solubility and stability of insoluble drugs, so that insoluble drugs can be developed into injectables.
Examples: Sulfobutyl betacyclodextrin is used to improve the solubility of docetaxel, voriconazole, ibuprofen and indomethacin; sulfobutyl betacyclodextrin is used to improve the stability of carmustine.
2. Application in oral formulation
Role: Solubilizer, stabilizer, improve the bioavailability of insoluble drugs.
Example: Sulfobutyl betacyclodextrin is used to improve the bioavailability of flunarizine, danazol, hydrogenated prednisone and prasugrel.
3、Application in ophthalmic preparations
Role: Solubilizer, stabilizer, reduce drug irritation.
Example: Sulfobutyl betacyclodextrin is used to improve the irritation and stability of furfuracoum, dipivoxylin, baroxacin and ganciclovir.
4、Application in the nasal preparation
Effects: Increase the permeability of the nasal mucosa, improve the solubility and stability of the drug, and improve the metabolic rate of the drug at the target site of administration.
Example: Sulfobutyl betacyclodextrin is used to improve the solubility and stability of midazolam.
5、Ointment softener
Effects: Improve the solubility and stability of drugs.
Example: Sulfobutyl betacyclodextrin is used to improve the solubility and stability of nimesulide.