Hydroxypropyl Betadex HPBCD for Solubility Enhancement in Pharmaceuticals
CAS Number: 128446-35-5
Product Category: Pharmaceutical Excipient
Main Function: Drug solubility enhancement and inclusion complex formation
Appearance: White or almost white amorphous powder
Water Solubility: Highly soluble in water
Applications: Drug formulation, injectable preparations, oral formulations, and topical drugs
Quality Standard: USP / EP / ChP Pharmaceutical Grade
Hydroxypropyl Betadex (HPBCD) is a chemically modified derivative of β-cyclodextrin, developed to enhance aqueous solubility and functional performance in pharmaceutical systems. The introduction of hydroxypropyl groups increases molecular flexibility and reduces crystallinity, resulting in significantly improved solubility compared to native cyclodextrin.
HPBCD forms inclusion complexes with hydrophobic active pharmaceutical ingredients (APIs), thereby improving apparent solubility, stability, and bioavailability. This mechanism supports the development of formulations for poorly soluble compounds across multiple dosage forms.
It is widely applied in oral, parenteral, topical, and ophthalmic formulations, contributing to enhanced drug performance and improved formulation robustness.
✔ Enhances drug solubility and bioavailability
✔ Improves stability of sensitive APIs
✔ Suitable for injectable, oral, and topical formulations
✔ Excellent safety profile and low toxicity
✔ Compatible with a wide range of pharmaceutical ingredients
Hydroxypropyl Betadex is widely used as a solubilizing and stabilizing excipient in pharmaceutical formulations across multiple dosage forms.
Used in parenteral formulations to improve solubility and prevent precipitation, ensuring safe and stable injectable solutions.
Enhances dissolution rate and bioavailability in tablets, capsules, and oral liquids, supporting consistent drug absorption.
Improves drug solubility in eye drop formulations while maintaining low irritation and high safety.
Facilitates rapid drug absorption through mucosal membranes in nasal sprays and inhalation systems.
Widely applied in veterinary formulations to improve drug performance and bioavailability.
With over 27 years of manufacturing experience, Xi’an Deli Biochemical Industry Co., Ltd. specializes in the production of cyclodextrin derivatives for pharmaceutical applications. Our core products include Hydroxypropyl Betadex (HPβCD), β-Cyclodextrin, and SBECD.
We supply high-quality excipients to pharmaceutical, veterinary, and chemical companies worldwide, supporting drug formulation, solubility enhancement, and advanced drug delivery systems.
Backed by stable production capacity and strong technical expertise, we provide consistent quality, regulatory support, and responsive service to meet the needs of global customers.
Hydroxypropyl Betadex is manufactured in accordance with major pharmacopoeial standards, including USP, EP, and ChP. Production is conducted under controlled conditions to ensure consistent quality and reproducibility across batches.
Quality control testing includes key parameters such as degree of substitution, identification, purity, and microbiological attributes, using validated analytical methods.
For detailed specifications and batch-specific data, including the Certificate of Analysis (COA), please contact us via the inquiry form.
For full quality data and the latest COA, as well as other technical documentation, please contact us through our website Send Inquiry form. Our team will respond promptly.
✔ Extensive experience in cyclodextrin production
✔ Pharma grade quality meeting USP and EP standards
✔ Reliable supply with strong production capacity
✔ Dedicated technical support for formulation development
✔ Trusted by customers worldwide
We provide flexible ordering options and reliable international delivery to support our global customers.
✔ T/T (Bank Transfer)
✔ L/C at sight
✔ Other payment terms can be discussed based on order volume and cooperation
✔ Express delivery (DHL, FedEx, UPS) for samples and small quantities
✔ Air freight for medium-volume orders
✔ Sea freight for bulk shipments
✔ Samples: typically available within 3–5 working days
✔ Bulk orders: depending on quantity and production schedule
We ensure safe packaging and reliable delivery to meet international shipping requirements.
Hydroxypropyl Betadex is used as a pharmaceutical excipient to enhance the solubility, stability, and bioavailability of poorly soluble drugs.
Yes. Pharmaceutical-grade HPBCD is widely used in injectable drug formulations and is included in several approved pharmaceutical products.
HPBCD forms inclusion complexes with hydrophobic drug molecules, allowing them to dissolve more easily in aqueous environments.
HPBCD is a modified form of β-cyclodextrin with hydroxypropyl groups that significantly improve water solubility and reduce toxicity.
It is mainly used in pharmaceutical formulations, veterinary drugs, and advanced drug delivery systems.
