Introduction
Hydroxypropyl Betadex (HPBCD), Sulfobutyl Ether Betadex Sodium (SBECD), and Betadex (β-Cyclodextrin). These excipients play a crucial role in the pharmaceutical and biopharmaceutical industries due to their unique ability to form inclusion complexes, improving the solubility, stability, and bioavailability of active pharmaceutical ingredients (APIs).
Cyclodextrins and their derivatives play pivotal roles in modern pharmaceutical formulations. Among them, Hydroxypropyl Beta-Cyclodextrin (HP-β-CD), Sulfobutylether Beta-Cyclodextrin Sodium (SBE-β-CD), and native Beta-Cyclodextrin (β-CD) have gained significant attention due to their unique properties. This article provides an in-depth comparison of these three cyclodextrin derivatives across multiple dimensions.
Chemical Structure and Modification
1. Betadex (β-Cyclodextrin) β-Cyclodextrin is the original form of cyclodextrin, composed of seven glucose units. It is commonly used in food and pharmaceuticals for its natural inclusion ability. However, it has limited aqueous solubility and may cause nephrotoxicity at high doses, which restricts its use in injectable formulations.
Applications: Food additives, oral pharmaceuticals, environmental decontamination.
2. Hydroxypropyl Betadex (HPBCD) HPBCD is a modified cyclodextrin where hydroxypropyl groups are added to enhance water solubility and reduce toxicity. It is widely used in oral, ophthalmic, and parenteral drugs. With excellent inclusion capabilities, HPBCD significantly improves the delivery of poorly soluble drugs.
Advantages:
- High water solubility- Suitable for oral and injectable formulations
Xi’an Deli Biochemical offers 500 tons annual capacity, with 3.3 tons per batch, ensuring stable and large-scale supply.
3. Sulfobutyl Ether Betadex Sodium (SBECD)SBECD is a highly water-soluble, anionic derivative designed specifically for parenteral use. Its safety and compatibility make it an ideal excipient in injectable drug formulations, especially for insoluble or sensitive APIs. SBECD is included in multiple FDA-approved injectables.
Advantages:
- Exceptional solubility- Enhanced drug stability
Xi’an Deli Biochemical produces 100 tons per year, 2.5 tons per batch, providing fast delivery, consistent quality, and competitive pricing.
Conclusion
This comprehensive comparison demonstrates that while β-CD serves basic needs, HP-β-CD offers the best balance of performance and cost for most pharmaceutical applications. SBE-β-CD remains the gold standard for high-risk parenteral formulations despite its premium price. The selection should be based on specific formulation requirements, route of administration, and budget considerations. Future developments in targeted drug delivery may further expand the applications of these versatile excipients.
This article presents a comparative analysis of three important cyclodextrin derivatives: Betadex (β-Cyclodextrin), Hydroxypropyl Betadex (HPBCD), and Sulfobutyl Ether Betadex Sodium (SBECD). Each plays a distinct role in enhancing drug solubility and stability, especially in pharmaceutical formulations. HPBCD and SBECD are advanced derivatives with better solubility and safety profiles compared to basic β-Cyclodextrin. Xi’an Deli Biochemical, with its large-scale production capabilities and stable quality, offers a competitive edge in supplying these essential excipients to the global market.
Why Choose Deli Biochemical?
As one of China’s leading manufacturers of cyclodextrin derivatives, Xi’an Deli Biochemical offers:
For more information or to request samples, please contact us: xadl@xadl.com.
