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Use of cyclodextrins as excipients in pharmaceutical products


To conduct an assessment of cyclodextrins used as excipients in pharmaceutical formulations, considering compounding, biopharmaceuticalpharmacokinetic, toxicological, regulatory, economic and commercial aspects.

Cyclodextrins are cyclic oligosaccharides used for the improvement of water-solubility and bioavailability of drugs. Because of the diverse types of application of cyclodextrins, several types of medicinal products may contain cyclodextrins. They are used for example in tablets, aqueous parenteral solutions, nasal sprays and eye drop solutions. Examples of the use of cyclodextrins in medicines on the European market are β-CD in cetirizine tablets and cisapride suppositories, γ-CD in minoxidil solution, and examples of the use of β-cyclodextrin derivatives are SBE-β-CD in the intravenous antimycotic voriconazole, HP-β-CD in the antifungal itraconazole, intravenous and oral solutions, and RM-β-CD in a nasal spray for hormone replacement therapy by 17β-estradiol. In Germany and Japan there are infusion products on the market, containing alprostadil (prostaglandin E1, PGE1) with α-CD.

In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of active substances poorly soluble in water, in order to increase their bioavailability and to improve stability. In addition, cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes, prevent drugdrug or drug-additive interactions within a formulation (all these properties are based on reduction of the free drug in solution), or to convert oils and liquid drugs into microcrystalline or amorphous powders.

Xi'an Deli Biochemical Industry Co., Ltd. is a high-tech enterprise specializing in research & development, production & sales of cyclodextrin and its derivatives.

Since its establishment on August 27, 1999, the company has been adhering to the quality policy of "focusing on accessories, quality first, honest service, striving for first-class". After more than 20 years of hard work and development, the company currently has products DELI Brand Hydroxypropyl Betadex, DELI     Brand Betadex Sulfobutyl Ether Sodium. The above products have been registered and filed with the FDA. The company's management system has passed ISO 9001:2015 certification.

Main products:


CAS No.: 182410-00-0

Standard : CP/USP/EP

DMF No.: 034772


CAS No.: 128446-35-5


DMF No.: 034773

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