Vonoprazan Fumarate CAS 1260141-27-2 API for Drug Development
Vonoprazan Fumarate CAS 1260141-27-2 is a pharmaceutical active pharmaceutical ingredient (API) used in drug development and pharmaceutical manufacturing, particularly for products requiring gastric acid suppression. As a potassium-competitive acid blocker (P-CAB), vonoprazan provides a different mechanism of gastric acid inhibition compared with conventional proton pump inhibitors. Xi’an Deli Biochemical Industry Co., Ltd. provides Vonoprazan Fumarate API for pharmaceutical research, formulation development, analytical evaluation, supplier qualification, and commercial manufacturing.
With more than 27 years of experience in the pharmaceutical and biochemical industry, Xi’an Deli specializes in pharmaceutical APIs and pharmaceutical excipients. We provide product information, samples, technical documentation, quality documents, packaging solutions, and commercial supply support for pharmaceutical customers and development partners in international markets.
Product Information
Product Name: Vonoprazan Fumarate
CAS Number: 1260141-27-2
Product Type: Active Pharmaceutical Ingredient (API)
Pharmaceutical Class: Potassium-Competitive Acid Blocker (P-CAB)
Grade: Pharmaceutical Grade
Development Code: TAK-438
Molecular Formula: C17H16FN3O2S · C4H4O4
Application: Gastrointestinal Pharmaceutical Products
Product Form: Please contact us for detailed product information
Sample: Available upon request
Packaging: Available according to quantity and customer requirements
Manufacturer: Xi’an Deli Biochemical Industry Co., Ltd.
What Is Vonoprazan Fumarate?
Vonoprazan Fumarate is the fumarate salt form of vonoprazan and belongs to the potassium-competitive acid blocker family. It is an important pharmaceutical ingredient for drug products designed to reduce gastric acid secretion.
Vonoprazan works by competitively inhibiting potassium binding to the gastric H+/K+-ATPase proton pump. This enzyme is responsible for the final step of gastric acid secretion. By inhibiting the proton pump, vonoprazan can suppress gastric acid production and provide a pharmacological approach for the treatment of acid-related gastrointestinal conditions.
The unique P-CAB mechanism is one of the main characteristics that distinguishes vonoprazan from traditional proton pump inhibitors. Because of its pharmacological profile, Vonoprazan Fumarate CAS 1260141-27-2 has become an important API for pharmaceutical development in the gastrointestinal therapeutic area.
Mechanism of Action
The gastric proton pump, known as H+/K+-ATPase, plays a central role in gastric acid secretion. Vonoprazan competitively blocks potassium binding to this proton pump and thereby inhibits the secretion of gastric acid.
Unlike conventional proton pump inhibitors that require activation in an acidic environment, vonoprazan belongs to the P-CAB class and directly targets the gastric proton pump through potassium-competitive inhibition. This mechanism provides a different approach to acid suppression and is an important consideration during pharmaceutical development.
For pharmaceutical companies evaluating Vonoprazan Fumarate API, understanding its mechanism of action is important when developing formulations, selecting appropriate analytical methods, and evaluating the API for specific gastrointestinal drug products.
Pharmaceutical Applications
Vonoprazan Fumarate is primarily associated with pharmaceutical products requiring gastric acid suppression. Its applications cover several important areas in gastrointestinal drug development.
Gastroesophageal Reflux Disease
Vonoprazan is used in pharmaceutical products for the management of gastroesophageal reflux disease (GERD). Its gastric acid suppression mechanism makes it a relevant API for drug products targeting acid-related reflux conditions.
Erosive Esophagitis
Erosive esophagitis is associated with damage to the esophageal mucosa caused by gastric acid exposure. Vonoprazan-based pharmaceutical products can be used in this therapeutic area because of the API's ability to suppress gastric acid secretion.
Helicobacter Pylori Eradication
One important application of vonoprazan is in pharmaceutical regimens for Helicobacter pylori eradication. Vonoprazan may be used in combination with appropriate antibacterial agents. Its acid-suppressing activity is an important component of combination treatment strategies.
Gastric Ulcers
Vonoprazan-based products may be used in the treatment of acid-related gastric ulcers. Pharmaceutical developers can evaluate Vonoprazan Fumarate CAS 1260141-27-2 as an API for suitable gastrointestinal formulations.
Duodenal Ulcers
The acid-suppressing activity of vonoprazan also makes it relevant to pharmaceutical products for duodenal ulcer treatment. Specific indications and dosage regimens should follow the applicable regulatory requirements and approved product information in the target market.
Combination Pharmaceutical Products
Vonoprazan can be incorporated into combination pharmaceutical products, particularly products designed for Helicobacter pylori eradication. Combination products may contain vonoprazan together with appropriate antibacterial active ingredients according to the approved formulation and regulatory requirements.
Vonoprazan Fumarate for Drug Development
Vonoprazan Fumarate CAS 1260141-27-2 can be evaluated at different stages of pharmaceutical drug development. Pharmaceutical companies may require API samples and technical information during laboratory research, formulation development, analytical method development, pilot production, supplier qualification, and commercial manufacturing.
Laboratory Research: API samples can be used for initial identification, analytical evaluation, and pharmaceutical research.
Analytical Method Development: Pharmaceutical laboratories may develop and validate analytical methods for identification, assay, related substances, and other relevant quality attributes.
Formulation Development: The API can be evaluated during formulation development for appropriate pharmaceutical dosage forms.
Compatibility Studies: Pharmaceutical developers may evaluate compatibility between vonoprazan and selected excipients during formulation development.
Dissolution Studies: Finished formulations can be evaluated through appropriate dissolution testing during pharmaceutical development.
Stability Studies: Stability studies can be conducted according to the requirements of the pharmaceutical development project and applicable guidelines.
Process Development: The API may be evaluated during laboratory-scale, pilot-scale, and commercial manufacturing process development.
Supplier Qualification: Pharmaceutical companies can evaluate the API source through samples, specifications, COA, technical documentation, quality communication, and other qualification requirements.
Key Benefits of Vonoprazan Fumarate
P-CAB Mechanism: Vonoprazan belongs to the potassium-competitive acid blocker class and provides a distinct mechanism for gastric acid suppression.
Established Pharmaceutical Application: Vonoprazan has applications in gastrointestinal pharmaceutical products, including acid-related conditions and Helicobacter pylori eradication regimens.
Suitable for Drug Development: The API can be evaluated during pharmaceutical research, formulation development, analytical development, supplier qualification, and commercial manufacturing.
Defined Product Identity: CAS 1260141-27-2 provides a clear identification reference for pharmaceutical sourcing and technical communication.
Technical Support: Product specifications, COA, SDS, technical information, and other available documents can be discussed according to project requirements.
Quality Control and API Evaluation
Quality control is an essential part of pharmaceutical API evaluation. When sourcing Vonoprazan Fumarate API, pharmaceutical customers may evaluate product identity, assay, related substances, residual solvents, elemental impurities, water content, physical characteristics, and other applicable quality attributes.
Identification: Confirmation of the chemical identity of the API through appropriate analytical methods.
Assay: Determination of the active ingredient content according to the applicable specification.
Related Substances: Evaluation and control of relevant organic impurities and degradation products.
Residual Solvents: Evaluation according to applicable pharmaceutical quality requirements.
Elemental Impurities: Assessment according to applicable pharmaceutical quality and regulatory expectations.
Stability: Evaluation of product stability under appropriate storage conditions.
Technical Documentation
Technical documentation is important for API evaluation, supplier qualification, formulation development, and regulatory preparation. Xi’an Deli can provide available documentation according to the customer's project requirements.
Certificate of Analysis (COA): Batch-specific quality information can be provided according to the applicable requirements.
Product Specification: Product testing items and acceptance criteria can be provided for evaluation.
Safety Data Sheet (SDS): Safety, handling, transportation, and storage information.
Technical Data Sheet (TDS): Product-related technical information can be provided according to availability.
Packaging Information: Packaging materials and available package sizes can be discussed according to order requirements.
Additional Documentation: Other quality and technical documents can be discussed based on customer qualification and regulatory requirements.
Vonoprazan Fumarate Sample
Samples of Vonoprazan Fumarate CAS 1260141-27-2 can be discussed for laboratory testing, analytical method development, formulation research, and supplier evaluation.
When requesting a sample, please provide the required quantity, destination country, company information, intended application, and any specific quality or documentation requirements. This information allows our team to confirm the appropriate sample and shipping arrangement.
Packaging and Storage
Proper packaging is important for pharmaceutical APIs during storage, handling, and international transportation. Xi’an Deli can discuss packaging options according to order quantity, transportation method, destination country, and customer requirements.
Detailed information regarding package sizes, packaging materials, storage conditions, and transportation requirements can be provided according to the specific project.
Supply for Different Pharmaceutical Project Stages
Different pharmaceutical projects require different quantities and levels of technical support. Xi’an Deli can communicate with customers according to their development stage and procurement requirements.
Laboratory Stage: Small quantities can be discussed for initial laboratory evaluation and analytical testing.
Formulation Development: Product information and available technical documentation can support formulation development projects.
Pilot Production: Quantity, packaging, documentation, and delivery requirements can be discussed for pilot-scale projects.
Supplier Qualification: Product samples, specifications, COA, SDS, and other available documents can be provided according to qualification requirements.
Commercial Procurement: Larger quantities, packaging, delivery schedules, and commercial terms can be discussed for qualified projects.
Company Information
Xi’an Deli Biochemical Industry Co., Ltd. was established in 1999 and has more than 27 years of experience in the pharmaceutical and biochemical industry. We specialize in the development, manufacturing, and international supply of pharmaceutical APIs and pharmaceutical excipients.
Our product portfolio includes Vonoprazan Fumarate, Glucosamine Sulfate Sodium Chloride, Hydroxypropyl Betadex (HPBCD), and Betadex Sulfobutyl Ether Sodium (SBECD). Our products are supplied for pharmaceutical development, formulation research, manufacturing, and other pharmaceutical applications.
Xi’an Deli has extensive experience serving international pharmaceutical customers. We provide product information, samples, quality documentation, packaging solutions, quotation support, and international shipment coordination according to customer requirements.
The video provides an overview of Xi’an Deli Biochemical Industry Co., Ltd., our pharmaceutical ingredient portfolio, manufacturing capabilities, and international pharmaceutical supply services.
Why Choose Xi’an Deli?
27+ Years of Industry Experience
Xi’an Deli has more than 27 years of experience in the pharmaceutical and biochemical industry. Our experience covers pharmaceutical APIs, pharmaceutical excipients, product development, quality management, and international supply.
API and Pharmaceutical Excipient Portfolio
Our portfolio includes pharmaceutical APIs and excipients for different pharmaceutical applications. In addition to Vonoprazan Fumarate, our established cyclodextrin products include Hydroxypropyl Betadex (HPBCD) and Betadex Sulfobutyl Ether Sodium (SBECD).
Technical and Quality Support
We understand that pharmaceutical customers require more than a product quotation. During supplier evaluation, customers may need specifications, COA, SDS, technical information, samples, packaging details, and other quality documents. Our team can communicate these requirements directly with customers.
International Supply Experience
Xi’an Deli has experience serving customers in Europe, Asia, and other international markets. We support customers with product communication, sample arrangements, commercial quotations, packaging, documentation, and shipment coordination.
Frequently Asked Questions
1. What is Vonoprazan Fumarate?
Vonoprazan Fumarate is the fumarate salt form of vonoprazan and is a pharmaceutical API belonging to the potassium-competitive acid blocker (P-CAB) class.
2. What is the CAS number of Vonoprazan Fumarate?
The CAS number of Vonoprazan Fumarate is 1260141-27-2.
3. What is Vonoprazan Fumarate used for?
Vonoprazan is used in pharmaceutical products for gastric acid suppression and has applications in gastrointestinal conditions, including gastroesophageal reflux disease, erosive esophagitis, ulcers, and Helicobacter pylori eradication regimens.
4. Is Vonoprazan Fumarate an API?
Yes. Vonoprazan Fumarate CAS 1260141-27-2 is supplied as an active pharmaceutical ingredient for pharmaceutical development and manufacturing applications.
5. Can I request a sample?
Yes. Samples can be discussed for laboratory evaluation, analytical testing, formulation development, and supplier qualification.
6. What documents are available for evaluation?
Available documents may include COA, product specification, SDS, TDS, packaging information, and other supporting technical or quality documents according to project requirements.
7. Can Vonoprazan Fumarate be used for drug development?
Yes. The API can be evaluated during laboratory research, analytical method development, formulation development, pilot production, supplier qualification, and commercial pharmaceutical manufacturing.
8. How can I request a quotation?
Please provide your required quantity, destination country, application, specification requirements, packaging requirements, and documentation requirements. Our team will review the information and provide an appropriate quotation.
Request a Sample or Quotation
If your company is sourcing Vonoprazan Fumarate CAS 1260141-27-2 for pharmaceutical development, formulation research, supplier qualification, or commercial manufacturing, Xi’an Deli would be pleased to discuss your requirements.
Required Quantity: Please provide the quantity required for your project.
Destination: Please provide the destination country and delivery location.
Application: Please let us know whether the API is intended for laboratory research, formulation development, registration, or commercial manufacturing.
Specification: Please provide your target specification or applicable pharmacopoeial requirements if available.
Documentation: Please let us know if you require specific technical, quality, or regulatory documents.
Based on your requirements, we can provide available product information, technical documents, samples, packaging details, delivery information, and quotation support.
Contact Xi’an Deli Biochemical Industry Co., Ltd. to learn more about Vonoprazan Fumarate CAS 1260141-27-2 and discuss your pharmaceutical development or API sourcing requirements.
With more than 27 years of industry experience, Xi’an Deli is committed to providing pharmaceutical ingredients, technical support, consistent quality, and professional international supply services to customers worldwide.
