Vonoprazan Fumarate CAS 1260141-27-2 for Pharmaceutical Applications
Vonoprazan Fumarate CAS 1260141-27-2 is a pharmaceutical active pharmaceutical ingredient (API) belonging to the potassium-competitive acid blocker (P-CAB) class. It is used in pharmaceutical products for gastric acid suppression and is an important API for gastrointestinal drug development. Xi’an Deli Biochemical Industry Co., Ltd. provides Vonoprazan Fumarate API for pharmaceutical research, formulation development, supplier qualification, and commercial manufacturing.
With more than 27 years of experience in the pharmaceutical and biochemical industry, Xi’an Deli specializes in the development, manufacturing, and international supply of pharmaceutical APIs and pharmaceutical excipients. We support pharmaceutical companies, distributors, formulation developers, and research organizations with product information, samples, quality documentation, packaging solutions, and commercial supply.
Product Information
Product Name: Vonoprazan Fumarate
CAS No.: 1260141-27-2
Product Type: Active Pharmaceutical Ingredient (API)
Pharmaceutical Class: Potassium-Competitive Acid Blocker (P-CAB)
Grade: Pharmaceutical Grade
Development Code: TAK-438
Molecular Formula: C21H20FN3O6S
Molecular Weight: 461.46 g/mol
Application: Gastrointestinal Pharmaceutical Products
Product Form: Please contact us for detailed product information
Sample: Available upon request
Packaging: Available according to quantity and customer requirements
Manufacturer: Xi’an Deli Biochemical Industry Co., Ltd.
What Is Vonoprazan Fumarate?
Vonoprazan Fumarate is the fumarate salt form of vonoprazan and belongs to the potassium-competitive acid blocker family. Vonoprazan is designed to inhibit the gastric H+/K+-ATPase proton pump by competitively blocking potassium binding.
The gastric proton pump plays an important role in the final stage of gastric acid secretion. By inhibiting this target, vonoprazan reduces gastric acid production and provides an important pharmacological approach for pharmaceutical products designed for acid-related gastrointestinal conditions.
Because of its mechanism of action, Vonoprazan Fumarate API is an important pharmaceutical ingredient for drug products requiring gastric acid suppression. The API can be evaluated during pharmaceutical research, formulation development, analytical testing, supplier qualification, and commercial manufacturing.
Mechanism of Action
Vonoprazan acts on the gastric H+/K+-ATPase, also known as the gastric proton pump. It competitively inhibits potassium binding to the proton pump and thereby reduces hydrogen ion secretion into the stomach.
This mechanism distinguishes vonoprazan from conventional proton pump inhibitors (PPIs), which require activation in an acidic environment before inhibiting the proton pump. The P-CAB mechanism provides a different approach to gastric acid suppression and is one of the key characteristics of Vonoprazan Fumarate CAS 1260141-27-2.
Pharmaceutical Applications of Vonoprazan Fumarate
Vonoprazan Fumarate has multiple pharmaceutical applications associated with gastric acid suppression. Pharmaceutical companies may use this API in the development and manufacture of products for different gastrointestinal indications.
Gastroesophageal Reflux Disease
Vonoprazan is used in pharmaceutical products for the treatment of acid-related conditions such as gastroesophageal reflux disease (GERD). Gastric acid suppression can help manage acid exposure associated with reflux-related conditions.
Erosive Esophagitis
Erosive esophagitis is associated with repeated exposure of the esophageal mucosa to gastric acid. Vonoprazan-based pharmaceutical products can be used in this therapeutic area because of the acid-suppressing action associated with the P-CAB mechanism.
Helicobacter pylori Eradication
One important application of vonoprazan is in Helicobacter pylori eradication therapy. Vonoprazan can be used as part of combination treatment with appropriate antibacterial agents. Its gastric acid suppression mechanism is an important component of these pharmaceutical regimens.
Gastric Ulcer Treatment
Vonoprazan-based pharmaceutical products are used in the management of acid-related gastric ulcers. Pharmaceutical developers may evaluate Vonoprazan Fumarate API for pharmaceutical products targeting these gastrointestinal conditions.
Duodenal Ulcer Treatment
The gastric acid suppression properties of vonoprazan make it relevant to pharmaceutical products used in the management of duodenal ulcers. The specific indication and treatment regimen should follow applicable regulatory requirements and approved product information in each market.
Acid-Related Gastrointestinal Conditions
The mechanism of action of vonoprazan makes it relevant to pharmaceutical development for various acid-related gastrointestinal disorders. Pharmaceutical companies can evaluate the API according to their target indication, formulation strategy, and applicable regulatory requirements.
Pharmaceutical Combination Products
Vonoprazan may be incorporated into combination pharmaceutical products, particularly therapeutic regimens where gastric acid suppression is combined with antibacterial treatment. This makes Vonoprazan Fumarate an important API for pharmaceutical companies developing gastrointestinal combination therapies.
Vonoprazan Fumarate for Pharmaceutical Development
For pharmaceutical companies developing generic or innovative formulations, Vonoprazan Fumarate CAS 1260141-27-2 can be evaluated at different stages of pharmaceutical development.
Laboratory Evaluation: Initial testing can be performed to confirm API identity and evaluate relevant quality characteristics.
Analytical Method Development: Analytical methods can be developed or evaluated for identification, assay, related substances, and other quality attributes.
Formulation Development: The API can be evaluated during dosage-form development and pharmaceutical formulation studies.
Compatibility Studies: Pharmaceutical developers may evaluate API compatibility with selected excipients during formulation development.
Dissolution Studies: Formulation performance can be evaluated through appropriate dissolution and pharmaceutical quality studies.
Stability Studies: API and finished formulation stability can be evaluated according to the requirements of the development project.
Process Development: The API can be evaluated during laboratory, pilot-scale, and manufacturing process development.
Supplier Qualification: Pharmaceutical companies can assess the API source through samples, specifications, COA, technical documents, and quality communication.
Commercial Manufacturing: Larger quantities can be discussed for qualified pharmaceutical manufacturing projects.
Quality Considerations for Vonoprazan Fumarate API
The quality of an API is an important consideration during pharmaceutical development and manufacturing. For Vonoprazan Fumarate API, pharmaceutical customers may evaluate several quality attributes during supplier qualification.
Identification: Confirmation of the chemical identity of the API.
Assay: Determination of the active ingredient content.
Related Substances: Evaluation and control of specified and unspecified impurities.
Residual Solvents: Evaluation according to applicable pharmaceutical requirements.
Elemental Impurities: Assessment according to relevant pharmaceutical quality and regulatory expectations.
Stability: Evaluation of product stability under appropriate storage conditions.
Batch Consistency: Consistent quality between batches is important for formulation development and commercial manufacturing.
Technical Documents and Quality Support
Technical documentation is an important part of pharmaceutical API evaluation and supplier qualification. Xi’an Deli can provide available product and quality documents according to customer requirements and project stage.
Certificate of Analysis (COA): Available according to product and batch requirements.
Product Specification: Product quality requirements and testing information.
Safety Data Sheet (SDS): Safety, handling, transportation, and storage information.
Technical Data Sheet (TDS): Available technical and product information.
Packaging Information: Packaging materials and available package options can be discussed.
Analytical Information: Relevant analytical information can be provided according to project requirements.
Other Supporting Documents: Additional documents can be discussed based on customer qualification and regulatory requirements.
Vonoprazan Fumarate Sample
Samples of Vonoprazan Fumarate CAS 1260141-27-2 can be provided for laboratory evaluation, analytical testing, formulation development, and supplier qualification.
For a sample request, please provide the required quantity, destination country, company information, intended application, and any specific quality or documentation requirements.
Packaging and Storage
Packaging is an important consideration for pharmaceutical APIs during storage, handling, and international transportation. Xi’an Deli can discuss suitable packaging options according to order quantity, transportation method, destination, and customer requirements.
For detailed information regarding available package sizes, packaging materials, storage conditions, and transportation requirements, please contact our sales team.
Company Information
Xi’an Deli Biochemical Industry Co., Ltd. was established in 1999 and has more than 27 years of experience in the pharmaceutical and biochemical industry. We specialize in the development, manufacturing, and international supply of pharmaceutical APIs and pharmaceutical excipients.
Our product portfolio includes Vonoprazan Fumarate, Glucosamine Sulfate Sodium Chloride, Hydroxypropyl Betadex (HPBCD), and Betadex Sulfobutyl Ether Sodium (SBECD). We provide product samples, technical documentation, quality information, packaging solutions, and commercial supply support for pharmaceutical customers worldwide.
With established manufacturing capabilities and international export experience, Xi’an Deli supports customers throughout different stages of pharmaceutical projects, including laboratory evaluation, formulation development, supplier qualification, registration support, and commercial procurement.
The video above provides an overview of Xi’an Deli Biochemical Industry Co., Ltd., our pharmaceutical ingredient business, manufacturing capabilities, product portfolio, and commitment to quality and international pharmaceutical supply.
Why Choose Xi’an Deli?
27+ Years of Pharmaceutical Industry Experience
Xi’an Deli Biochemical Industry Co., Ltd. was established in 1999 and has more than 27 years of experience in the pharmaceutical and biochemical industry. Our long-term experience provides a strong foundation for pharmaceutical ingredient manufacturing, quality management, technical support, and international supply.
Professional API and Pharmaceutical Excipient Portfolio
Our product portfolio includes pharmaceutical APIs and excipients. In addition to Vonoprazan Fumarate, our products include Glucosamine Sulfate Sodium Chloride, Hydroxypropyl Betadex (HPBCD), and Betadex Sulfobutyl Ether Sodium (SBECD).
Manufacturing Capability
Xi’an Deli operates a dedicated production facility and has established manufacturing and quality control processes for pharmaceutical ingredients. Our manufacturing capabilities allow us to support both development-stage and commercial supply requirements.
Quality Management
Quality management is integrated into our manufacturing and supply process. We maintain controlled production procedures, analytical testing, batch documentation, and quality inspection to support consistent product quality.
Technical Documentation Support
Pharmaceutical customers often require detailed technical and quality information before approving an API source. Our team can communicate with customers regarding specifications, COA, SDS, technical documents, packaging information, samples, and other project requirements.
International Pharmaceutical Supply
Xi’an Deli serves pharmaceutical customers and business partners in international markets including Europe, Asia, and other regions. We have experience with international communication, export documentation, packaging requirements, and shipment arrangements.
Support from Sample to Commercial Order
We can support customers at different stages of pharmaceutical projects, from initial sample evaluation and analytical testing to formulation development, supplier qualification, pilot-scale production, and commercial procurement.
Flexible Supply and Customer Communication
Different pharmaceutical projects have different requirements for quantity, specification, packaging, documentation, and delivery. Our sales and technical teams communicate directly with customers to understand project requirements and provide an appropriate supply solution.
Global Pharmaceutical Applications
The pharmaceutical applications of vonoprazan have created demand for reliable sources of Vonoprazan Fumarate API for pharmaceutical development and manufacturing. Potential customers include pharmaceutical manufacturers, generic drug developers, distributors, contract development organizations, and research organizations.
For international API sourcing, pharmaceutical companies need more than product availability. They may also require consistent quality, appropriate documentation, suitable packaging, professional communication, and reliable delivery arrangements.
Xi’an Deli combines pharmaceutical manufacturing experience with international supply experience to support customers throughout the sourcing and qualification process.
Frequently Asked Questions
1. What is Vonoprazan Fumarate?
Vonoprazan Fumarate is the fumarate salt form of vonoprazan and belongs to the potassium-competitive acid blocker (P-CAB) class. It is used as a pharmaceutical API for gastric acid suppression.
2. What is the CAS number of Vonoprazan Fumarate?
The CAS number for the product is 1260141-27-2. Customers should confirm the CAS identifier required for their regulatory and purchasing documentation.
3. What is Vonoprazan Fumarate used for?
Vonoprazan Fumarate is used as an API in pharmaceutical products for gastric acid suppression. Its applications include acid-related gastrointestinal conditions and Helicobacter pylori eradication combination regimens.
4. What pharmaceutical class does Vonoprazan belong to?
Vonoprazan belongs to the potassium-competitive acid blocker (P-CAB) class.
5. How does Vonoprazan work?
Vonoprazan competitively inhibits potassium binding at the gastric H+/K+-ATPase proton pump, thereby reducing gastric acid secretion.
6. Can Vonoprazan Fumarate be used for pharmaceutical development?
Yes. Vonoprazan Fumarate can be evaluated for pharmaceutical research, formulation development, analytical testing, generic drug development, supplier qualification, and commercial manufacturing.
7. Can I request a Vonoprazan Fumarate sample?
Yes. Samples can be discussed for laboratory evaluation and supplier qualification. Please provide your required sample quantity and destination country.
8. What documents are available for Vonoprazan Fumarate API?
Available documents may include COA, product specification, SDS, TDS, packaging information, analytical information, and other supporting quality documents according to project requirements.
9. How can I request a quotation?
Please provide your required quantity, destination country, intended application, target specification, packaging requirements, and documentation requirements. Our team will review your requirements and provide product information and a quotation accordingly.
Request Vonoprazan Fumarate API Information
If you are sourcing Vonoprazan Fumarate CAS 1260141-27-2 for pharmaceutical development, formulation research, generic drug development, supplier qualification, or commercial manufacturing, Xi’an Deli Biochemical Industry Co., Ltd. welcomes your inquiry.
Please send us your required quantity, destination country, application, target specification, packaging requirements, and documentation requirements. We can provide available product information, samples, technical documents, packaging details, and quotation support according to your project.
Contact Xi’an Deli to learn more about Vonoprazan Fumarate CAS 1260141-27-2 and discuss your pharmaceutical API requirements.
