DELI is a leading China Betadex Pharmaceutical Grade manufacturers, suppliers and exporter. Beta Cyclodextrin CAS 7585-39-9 is a high purity and quality chemical.
Betadex Pharmaceutical Grade is a high purity and quality chemical, and DELI is very famous in China. Betadex is a nonreducing cyclic compound composed of seven alpha-(1–4) linked D-glucopyranosyl units. It contains NLT 98.0% and NMT 102.0% of betadex (C6H10O5)7, and is calculated on the anhydrous basis.
Product Name: Beta Cyclodextrin
CAS: 7585-39-9Abbreviation: BCD; betadex
For the preparation method of beta-cyclodextrin inclusion complex, a suitable method should be selected according to the properties of the drug molecules, the ratio of feeding materials, the equipment conditions, etc. in the application.
1.Saturated aqueous solution method: This is the most widely used method in current research. It has the characteristics of simple preparation method, short operation time and high inclusion rate. At a certain temperature, the beta cyclodextrin is prepared into a saturated aqueous solution, the drug is added in a certain proportion, stirred and mixed, the precipitated solid inclusion compound is allowed to stand, suction filtered, washed with an organic solvent, and dried at low temperature to obtain the inclusion compound. In the inclusion process of saturated aqueous solution, the main factors affecting the inclusion process are the host-guest molecule feeding ratio, inclusion temperature, inclusion time, stirring method, drying method and so on. The optimal inclusion conditions are generally obtained by orthogonal experiments or uniform design at different levels according to their influencing factors.
2.Grinding method: Beta cyclodextrin is mixed with 2 to 5 times the amount of water, and it is evenly ground. Add the drug (insoluble drugs should be dissolved in an organic solvent first), fully grind and mix to a paste, and then dry at low temperature. , washed with organic solvent, suction filtered and dried to obtain powder inclusion compound. The manual grinding method is time-consuming and labor-intensive, and is only suitable for small-scale production. The high efficiency and high inclusion rate of the colloid grinding method enable the realization of industrialized production. The grinding time and feeding ratio will have a certain influence on the inclusion rate.
3.Ultrasonic method: Dissolve the solid drug or solvent and mix it with a saturated aqueous solution of beta-cyclodextrin, use an ultrasonic cleaning machine or an ultrasonic crusher to ultrasonicate the mixture for a suitable time at an appropriate power, and then filter and wash the precipitated precipitate. , and dried to obtain the inclusion compound. This method is simple, fast and suitable for mass production. Ultrasound time, temperature, and material ratio can affect the inclusion rate.
4.Other methods: In addition, there are freeze drying, spray drying. These methods are rarely used in practice, and have disadvantages such as low clathrate yield and higher requirements for the properties of the clathrates. Freeze-drying is suitable for heating and drying drugs that are easily decomposed, and spray-drying is suitable for drugs with relatively stable properties when exposed to heat.