CAS 182410-00-0 Sulfobutyl beta cyclodextrin Ether Sodium Salts is a cyclodextrin derivativea and a China DELI's new kind of pharmaceutical excipients.
CAS 182410-00-0 Sulfobutyl beta cyclodextrin Ether Sodium Salts
CAS NO: 128410-00-0
Molecular formula: C42H70-nO35•(C4H8SO3Na)n
Specification: 500g/Bag; 1kg/Bag; 10kg/bag/drum; or as your requirement
Period of validity: 36 months
Grade:Injection grade
Application:Pharmaceuticals feild
Sulfobutyl Ether Beta cyclodextrin Sodium salt is a sodium salt produced when Betadex is alkylated by 1,4-butanesulfonic acid lactone under alkaline conditions. It is an anion, highly water-soluble Betadex derivative. Sulfobutyl Ether Beta cyclodextrin Sodium salt can be well combined with the drug molecules to form non-covalent thereby enhancing the stability, water solubility, and safety of the drug, reducing its renal toxicity, easing drug hemolysis, controlling drug release rate, covering bad smell, etc.
1.In an oral preparation:
The solubility difference is one of the main reasons of low oral bioavailability of insoluble drugs, Betadex Sulfobutyl Ether Sodium can be used as inclusion material and insoluble drug clathrate formation, so as to improve the solubility of insoluble drugs, can increase the oral bioavailability. In addition, it can increase the stability of the drug, reduce the irritation of the drug, and conceal the bad smell or taste of the medicine.
2.In the injection:
Betadex Sulfobutyl Ether Sodium not only can increase drug solubility, improve the stability and safety of the drug, it can reduce the stimulation to the injection site of administration, the drug quickly reaches the blood concentration required, prolong the time of drug action.
3.In the nasal administration preparation:
Intranasal drug having rapid absorption, fast acting, high bioavailability, convenient administration, easy to be accepted by patients, and can avoid the liver first pass effect and other advantages, has become one of the hotspots in pharmaceutical research. However, due to low penetration of nasal drugs, many enzymes in the nasal cavity can cause degradation and nasal adhesion
Membrane cilia have strong scavenging function and other physiological factors, which affect the absorption of drugs. CAS 182410-00-0 Sulfobutyl beta cyclodextrin Ether Sodium Salts can improve the solubility and stability of drugs, increase the permeability of nasal mucosa, and improve the bioavailability of nasal medicine.
