Hydroxypropyl Betadex (HPBCD) CAS 128446-35-5 Pharmaceutical Excipient for Drug Formulation
CAS Number: 128446-35-5
Product Category: Pharmaceutical Excipient
Main Function: Drug solubility enhancement and inclusion complex formation
Appearance: White or almost white amorphous powder
Water Solubility: Highly soluble in water
Applications: Drug formulation, injectable preparations, oral formulations, and topical drugs
Quality Standard: USP / EP / ChP Pharmaceutical Grade
Hydroxypropyl Betadex (HPBCD), also known as Hydroxypropyl Beta Cyclodextrin, is a chemically modified derivative of β-cyclodextrin widely used as a pharmaceutical excipient and cyclodextrin drug solubilizer for modern drug formulation. By introducing hydroxypropyl groups into the β-cyclodextrin structure, the compound achieves significantly improved water solubility and better compatibility in pharmaceutical systems.
HPBCD functions as a solubilizing and complexing agent capable of forming inclusion complexes with hydrophobic drug molecules. This property helps improve drug solubility, stability, and bioavailability, making it particularly valuable for the development of poorly water-soluble drugs.
Hydroxypropyl Betadex is widely used in oral, injectable, and topical pharmaceutical formulations as well as in pharmaceutical research and drug development.
Product Name: Hydroxypropyl Betadex (HPBCD)
Chemical Name: Hydroxypropyl Beta Cyclodextrin
CAS Number: 128446-35-5
Product Type: Pharmaceutical Excipient
Main Function: Solubility enhancement and inclusion complex formation
Applications: Oral, injectable, topical and ophthalmic formulations
Quality Standard: USP / EP / ChP
Xi’an Deli Biochemical Industry Co., Ltd. was established in 1999 and specializes in the manufacturing of cyclodextrin derivatives and pharmaceutical excipients. With more than two decades of industry experience, the company provides reliable products and stable supply to pharmaceutical companies, research institutions, and distributors worldwide.
Deli Biochemical focuses on the production of Hydroxypropyl Betadex, Betadex Sulfobutyl Ether Sodium, and other pharmaceutical excipients used in drug formulation and pharmaceutical research.
The company is committed to quality management, stable production capacity, and long-term cooperation with global pharmaceutical partners. Deli Biochemical supplies Hydroxypropyl Betadex (HPBCD) and other cyclodextrin derivatives to pharmaceutical companies worldwide.
Hydroxypropyl Betadex (HPBCD) is widely recognized as an effective pharmaceutical excipient for improving drug formulation performance. Compared with native cyclodextrin, the hydroxypropyl modification significantly increases water solubility and reduces crystallinity, allowing HPBCD to interact more efficiently with poorly soluble active pharmaceutical ingredients.
One of the key technical advantages of Hydroxypropyl Betadex is its ability to form stable inclusion complexes with hydrophobic molecules. This unique property enables the encapsulation of drug molecules within the cyclodextrin cavity, improving their apparent solubility in aqueous environments and enhancing overall formulation stability.
In addition, HPBCD demonstrates excellent compatibility with a wide range of pharmaceutical formulation technologies. It can be used in oral, injectable, topical, and ophthalmic preparations without significantly affecting drug activity. Its high aqueous solubility and favorable safety profile make it particularly suitable for modern drug delivery systems.
Due to these advantages, Hydroxypropyl Betadex has become an important functional excipient for pharmaceutical research and industrial drug development, especially for formulations involving poorly soluble APIs.
| Item | Specification |
|---|---|
| Product Name | Hydroxypropyl Betadex |
| Synonyms | Hydroxypropyl Beta Cyclodextrin / HPBCD |
| CAS Number | 128446-35-5 |
| Appearance | White or almost white powder |
| Solubility | Freely soluble in water |
| Grade | Pharmaceutical Grade |
| Standard | USP / EP / ChP |
Packaging
Storage
Store in a tightly closed container in a cool and dry place, protected from moisture and direct sunlight.
Shelf Life
36 months under recommended storage conditions.
1.What is Hydroxypropyl Betadex used for?
Hydroxypropyl Betadex is mainly used as a pharmaceutical excipient to improve the solubility, stability, and bioavailability of poorly soluble drugs.
2.How does HPBCD improve drug solubility?
HPBCD forms inclusion complexes with hydrophobic drug molecules, allowing them to dissolve more easily in aqueous environments.
3.Is Hydroxypropyl Betadex safe for pharmaceutical use?
Hydroxypropyl Betadex is widely used in pharmaceutical formulations and is included in several pharmacopoeias such as USP and EP.
4.What types of drug formulations use HPBCD?
HPBCD can be used in oral, injectable, topical, and ophthalmic formulations.
5.Is Hydroxypropyl Betadex the same as beta cyclodextrin?
Hydroxypropyl Betadex is a modified derivative of beta cyclodextrin with significantly improved water solubility and better compatibility for pharmaceutical formulations.
• Over 20 years experience in cyclodextrin production
• Stable pharmaceutical grade quality
• Reliable global supply capability
• Professional technical support
For product specifications, quotation, or free sample requests of Hydroxypropyl Betadex (HPBCD), please contact our technical sales team.
We will respond within 24 hours and provide professional support for pharmaceutical formulation applications.
