SBE-β-CD Sulfobutylether-β-Cyclodextrin

SBE-β-CDSulfobutylether-β-Cyclodextrin, as a chemically modified β-CD, is a sulfobutylether β-cyclodextrin derivative. It always used as an excipient or a formulating agent to increase the solubility of poorly soluble agents.SBE-β-CD Sulfobutylether-β-Cyclodextrinis used for enhancing the aqueous solubility of lipophilic drugs. And SBE-β-CD is very safe. Because of SBE-beta-CD has polyanionic nature, SBE-beta-CD interacts very well with neutral drugs to facilitate solubility and chemical stability.

In vitro, the solubility of nimodipine in the presence of SBECD increased more than in the presence of HPBCD in distilled water. Nimodipine has more affinity because of the highest K1:1 value exhibited by SBE-β-CD,which be ascribed to the presence of the four-carbon butyl chain coupled with repulsion of the end group negative charges which allows for an “extension” of the hydrophobic region of the CD cavity. At 400 mM SBE-β-CD concentration, the solubility of progesterone was ~7000-fold greater than its intrinsic solubility, aided by the formation of SBE-β-CD-progesterone complex. In addition, to prevent the displacement of progesterone from the complex by gastrointestinal contents, it needs to optimize the progesterone oral formulations by increasing the levels of SBE-β-CD in the formulation.

In vivo efficecy test it shown that the SBE-β-CD (128 M?1) had a higher solubilizing ability than that of HP-β-CD (79 M?1) suggesting suggest that a simple mixing of SD-CS and SBE-β-CD can be potentially useful for the controlled release of a medicine for the continuous treatment of hypertension. In vivo absorption of the drug after oral administration to rats indicated the slow release characteristics of the SD-CS/SBE-β-CD composite in vitro.

SBE-β-CD  Sulfobutylether-β-Cyclodextrin

CAS 182410-00-0

[Molecular formula]: C42H70-nO35•(C4H8SO3Na)n

[Specification]: 500g/Bag; 1kg/Bag; 10kg/bag/drum; or as your requirement

[Category]: Pharmaceutical excipients

[Storage]: Seal preservation.

[Period of validity]: 36 months

SBE-β-CD Sulfobutylether-β-Cyclodextrin is a sodium salt produced when Betadex is alkylated by 1,4-butanesulfonic acid lactone under alkaline conditions. It is an anion, highly water-soluble Betadex derivative. Betadex Sulfobutyl Ether Sodium can be well combined with the drug molecules to form non-covalent thereby enhancing the stability, water solubility, and safety of  the drug, reducing its renal toxicity, easing drug hemolysis, controlling drug release rate, covering bad smell, etc.